RenalDB: A Knowledge Database for Kidney RNA Expression
Institute of Cardiovascular Regeneration, Goethe University Frankfurt
Accession: UG_GRCh38-5Frq-JZa3AKh9YJ6nRjgw
Description:mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881]
Name(s) MAPK8, JNK, JNK1, PRKM8, SAPK1
Other IDs:
Tax IDPositionStrandBiotype(s)
9606 10:48306639-48439360 + protein_coding
Expressed in:
  Adipose, Adrenal, Bladder, Brain, Breast, Colon, Epithelial Cells, Heart, HEK-293 Cells, HEK-293F Cells, HEK-293T Cells, HK-2 Cells, Kidney, Kidney Cortex, Kidney Tubules, Liver, Lung, Muscle, Nephron Progenitor Cells, Nephrons, Ovary, Placenta, Proximal Tubule, Testis
Enriched in:
  Bladder, Brain, Breast, Colon, Epithelial Cells, Heart, HEK-293 Cells, HEK-293T Cells, Kidney, Kidney Cortex, Liver, Lung, Nephron Progenitor Cells, Ovary, Testis
Specific to:
  None
Parents
None
Children
Accession Name Sequence Type Position Assembly
UT_GRCh385YOKupM8swD6n8DxANffDQ MAPK8-004 transcript 10:48306680-48420246 (+) GRCh38
UT_GRCh38D7Nfz8n569WcqqxdDVzWqQ MAPK8-007 transcript 10:48425854-48426612 (+) GRCh38
UT_GRCh38exJQNHoGqXW6Ck_COepLjw MAPK8-011 transcript 10:48401643-48439360 (+) GRCh38
UT_GRCh38Iwza6v5S6JPwLOn3Z2tiiA MAPK8-006 transcript 10:48306690-48439360 (+) GRCh38
UT_GRCh38kc-On0A7EMZegjnKIuZwcA MAPK8-009 transcript 10:48307026-48410144 (+) GRCh38
UT_GRCh38lLG9K_YQSuaaYp2qj49sqQ MAPK8-010 transcript 10:48308216-48410328 (+) GRCh38
UT_GRCh38MLGQt9dFPuWhlMYf9oRdJw MAPK8-001 transcript 10:48425189-48436440 (+) GRCh38
UT_GRCh38pWoHfOzeoVkMdshnX9vHYA MAPK8-003 transcript 10:48424569-48427410 (+) GRCh38
UT_GRCh38RwRdJYR7tUvAN8z1qqRCGw MAPK8-002 transcript 10:48429893-48435877 (+) GRCh38
UT_GRCh38SE1T4Ac1cQ9IEhKKLJgH7g MAPK8-202 transcript 10:48306639-48439357 (+) GRCh38
UT_GRCh38tkCGhLIbCVw7ZMs6s9CKHw MAPK8-201 transcript 10:48401612-48439357 (+) GRCh38
UT_GRCh38UvPLXnaWcRs4e5mqDhLf1w MAPK8-013 transcript 10:48401661-48425831 (+) GRCh38
UT_GRCh38vzwAQS0eoHOjPy4l0ZsCtw MAPK8-008 transcript 10:48306655-48410146 (+) GRCh38
UT_GRCh38xZL-uOZg4Tl6dXkiSG9O-g MAPK8-012 transcript 10:48401644-48439360 (+) GRCh38
UT_GRCh38ZMieaPsWsyYUH1ql8E9PXg MAPK8-005 transcript 10:48424519-48434898 (+) GRCh38
UT_GRCh38_DFHd6vsmqutNrWvp9nr6A MAPK8-014 transcript 10:48401648-48439360 (+) GRCh38

Expression Patterns




Heat Map
Numeric Values
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Gene Ontology
GO ID Domain Evidence Type GO Description
GO:0000165 biological_process IEA MAPK cascade
GO:0001503 biological_process IEA ossification
GO:0002102 cellular_component IEA podosome
GO:0002224 biological_process TAS toll-like receptor signaling pat
GO:0002755 biological_process TAS MyD88-dependent toll-like recept
GO:0002756 biological_process TAS MyD88-independent toll-like rece
GO:0004672 molecular_function IEA protein kinase activity
GO:0004674 molecular_function IDA protein serine/threonine kinase
GO:0004705 molecular_function IDA JUN kinase activity
GO:0004707 molecular_function IEA MAP kinase activity
GO:0005515 molecular_function IEA protein binding
GO:0005515 molecular_function IPI protein binding
GO:0005524 molecular_function IEA ATP binding
GO:0005622 cellular_component IEA intracellular
GO:0005634 cellular_component IDA nucleus
GO:0005654 cellular_component TAS nucleoplasm
GO:0005737 cellular_component IEA cytoplasm
GO:0005739 cellular_component IEA mitochondrion
GO:0005829 cellular_component IEA cytosol
GO:0005829 cellular_component TAS cytosol
GO:0006281 biological_process TAS DNA repair
GO:0006302 biological_process TAS double-strand break repair
GO:0006468 biological_process IEA protein phosphorylation
GO:0006468 biological_process IMP protein phosphorylation
GO:0006915 biological_process TAS apoptotic process
GO:0006950 biological_process TAS response to stress
GO:0007254 biological_process IDA JNK cascade
GO:0007254 biological_process TAS JNK cascade
GO:0007258 biological_process IDA JUN phosphorylation
GO:0009411 biological_process IDA response to UV
GO:0010468 biological_process IEA regulation of gene expression
GO:0010628 biological_process IMP positive regulation of gene expr
GO:0012501 biological_process TAS programmed cell death
GO:0016301 molecular_function IEA kinase activity
GO:0018105 biological_process IDA peptidyl-serine phosphorylation
GO:0018107 biological_process IDA peptidyl-threonine phosphorylati
GO:0018107 biological_process IMP peptidyl-threonine phosphorylati
GO:0019899 molecular_function IPI enzyme binding
GO:0031063 biological_process IMP regulation of histone deacetylat
GO:0031281 biological_process IMP positive regulation of cyclase a
GO:0032091 biological_process IDA negative regulation of protein b
GO:0032880 biological_process IDA regulation of protein localizati
GO:0034134 biological_process TAS toll-like receptor 2 signaling p
GO:0034138 biological_process TAS toll-like receptor 3 signaling p
GO:0034142 biological_process TAS toll-like receptor 4 signaling p
GO:0034146 biological_process TAS toll-like receptor 5 signaling p
GO:0034162 biological_process TAS toll-like receptor 9 signaling p
GO:0034166 biological_process TAS toll-like receptor 10 signaling
GO:0035033 molecular_function IMP histone deacetylase regulator ac
GO:0035666 biological_process TAS TRIF-dependent toll-like recepto
GO:0038095 biological_process TAS Fc-epsilon receptor signaling pa
GO:0038123 biological_process TAS toll-like receptor TLR1:TLR2 sig
GO:0038124 biological_process TAS toll-like receptor TLR6:TLR2 sig
GO:0042752 biological_process ISS regulation of circadian rhythm
GO:0042826 molecular_function IPI histone deacetylase binding
GO:0043065 biological_process TAS positive regulation of apoptotic
GO:0043066 biological_process IDA negative regulation of apoptotic
GO:0045087 biological_process TAS innate immune response
GO:0046686 biological_process IEA response to cadmium ion
GO:0048011 biological_process TAS neurotrophin TRK receptor signal
GO:0048511 biological_process IEA rhythmic process
GO:0051090 biological_process TAS regulation of sequence-specific
GO:0051247 biological_process IMP positive regulation of protein m
GO:0051403 biological_process TAS stress-activated MAPK cascade
GO:0070301 biological_process IEA cellular response to hydrogen pe
GO:0071222 biological_process IDA cellular response to lipopolysac
GO:0071260 biological_process IEP cellular response to mechanical
GO:0071732 biological_process IEA cellular response to nitric oxid
GO:0071803 biological_process IEA positive regulation of podosome
GO:0090045 biological_process IMP positive regulation of deacetyla
GO:0097190 biological_process TAS apoptotic signaling pathway
GO:0097193 biological_process TAS intrinsic apoptotic signaling pa
GO:0097300 biological_process IEA programmed necrotic cell death
GO:1900740 biological_process TAS positive regulation of protein i
GO:2000017 biological_process IEA positive regulation of determina
GO:2001235 biological_process IEA positive regulation of apoptotic

Homologs
Accession Description Species Homolog Type
UG_GRCm38_VN9B6z0wmjh7f81beiRCw Mapk8 10090 ortholog_one2one
UG_GRCz10sYm4cDOBL1Nvjm9g5QtL3g mapk8a 7955 ortholog_one2many
UG_GRCz10Uuq-_zjdyTve35mPJRQUZg mapk8b 7955 ortholog_one2many

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