RenalDB: A Knowledge Database for Kidney RNA Expression
Institute of Cardiovascular Regeneration, Goethe University Frankfurt
Accession: UG_GRCh38-DNCuWSzworw9hjbIqlXMw
Description:Rho-associated, coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251]
Name(s) ROCK1, p160ROCK
Other IDs:
Tax IDPositionStrandBiotype(s)
9606 18:20946906-21111851 - protein_coding
Expressed in:
  Adipose, Adrenal, Bladder, Brain, Breast, Colon, Epithelial Cells, Heart, HEK-293 Cells, HEK-293F Cells, HEK-293T Cells, HK-2 Cells, Kidney, Kidney Cortex, Kidney Tubules, Liver, Lung, Muscle, Nephron Progenitor Cells, Nephrons, Ovary, Placenta, Proximal Tubule, Testis
Enriched in:
  Adipose, Adrenal, Bladder, Brain, Breast, Colon, Epithelial Cells, Heart, HEK-293 Cells, HEK-293F Cells, Kidney, Kidney Cortex, Liver, Lung, Muscle, Ovary, Testis
Specific to:
  None
Parents
None
Children
Accession Name Sequence Type Position Assembly
UT_GRCh38-t5RF-IirfQ-CYCZGPYkmw ROCK1-001 transcript 18:20946906-21111851 (-) GRCh38
UT_GRCh384CLi8KR4t_l1laETDVtzAw ROCK1-004 transcript 18:20968485-20969354 (-) GRCh38
UT_GRCh38bthhQxkUf5v8EMspS3AIaw ROCK1-007 transcript 18:20949952-21111020 (-) GRCh38
UT_GRCh38PmvTZ7YNsRs56Gr8pGH8fw ROCK1-006 transcript 18:21045045-21049211 (-) GRCh38
UT_GRCh38sBkDpFMFj24j5t51mpHqBA ROCK1-003 transcript 18:20953290-20954870 (-) GRCh38
UT_GRCh38sY2rni3ZMMmAOk54C2Zarw ROCK1-002 transcript 18:20954854-20955467 (-) GRCh38
UT_GRCh38vZ3Lg96zNQ1wZwlWJiUXVA ROCK1-005 transcript 18:20969958-20982783 (-) GRCh38

Expression Patterns




Heat Map
Numeric Values
Loading figure. This may take some time for sequences with many hits.

Gene Ontology
GO ID Domain Evidence Type GO Description
GO:0000139 cellular_component IEA Golgi membrane
GO:0001726 cellular_component IEA ruffle
GO:0001726 cellular_component ISS ruffle
GO:0003383 biological_process IEA apical constriction
GO:0004672 molecular_function IEA protein kinase activity
GO:0004672 molecular_function TAS protein kinase activity
GO:0004674 molecular_function IDA protein serine/threonine kinase
GO:0004674 molecular_function IEA protein serine/threonine kinase
GO:0005515 molecular_function IEA protein binding
GO:0005515 molecular_function IPI protein binding
GO:0005524 molecular_function IEA ATP binding
GO:0005814 cellular_component IEA centriole
GO:0005829 cellular_component TAS cytosol
GO:0005856 cellular_component IEA cytoskeleton
GO:0005856 cellular_component ISS cytoskeleton
GO:0005886 cellular_component IEA plasma membrane
GO:0005886 cellular_component ISS plasma membrane
GO:0006468 biological_process IEA protein phosphorylation
GO:0006915 biological_process TAS apoptotic process
GO:0006921 biological_process TAS cellular component disassembly i
GO:0006939 biological_process TAS smooth muscle contraction
GO:0007159 biological_process IDA leukocyte cell-cell adhesion
GO:0007165 biological_process IEA signal transduction
GO:0007165 biological_process TAS signal transduction
GO:0007249 biological_process IMP I-kappaB kinase/NF-kappaB signal
GO:0007264 biological_process TAS small GTPase mediated signal tra
GO:0007266 biological_process TAS Rho protein signal transduction
GO:0007411 biological_process TAS axon guidance
GO:0012501 biological_process TAS programmed cell death
GO:0016525 biological_process IMP negative regulation of angiogene
GO:0017048 molecular_function IEA Rho GTPase binding
GO:0022614 biological_process IDA membrane to membrane docking
GO:0030027 cellular_component IEA lamellipodium
GO:0030027 cellular_component ISS lamellipodium
GO:0030036 biological_process IEA actin cytoskeleton organization
GO:0030036 biological_process TAS actin cytoskeleton organization
GO:0030155 biological_process TAS regulation of cell adhesion
GO:0030866 biological_process IGI cortical actin cytoskeleton orga
GO:0030866 biological_process IMP cortical actin cytoskeleton orga
GO:0032059 cellular_component IEA bleb
GO:0032060 biological_process IEA bleb assembly
GO:0032091 biological_process IDA negative regulation of protein b
GO:0032956 biological_process IDA regulation of actin cytoskeleton
GO:0032956 biological_process TAS regulation of actin cytoskeleton
GO:0032970 biological_process IEA regulation of actin filament-bas
GO:0035509 biological_process IGI negative regulation of myosin-li
GO:0035509 biological_process IMP negative regulation of myosin-li
GO:0035556 biological_process IEA intracellular signal transductio
GO:0043524 biological_process IEA negative regulation of neuron ap
GO:0045616 biological_process IMP regulation of keratinocyte diffe
GO:0046872 molecular_function IEA metal ion binding
GO:0048010 biological_process TAS vascular endothelial growth fact
GO:0048013 biological_process TAS ephrin receptor signaling pathwa
GO:0050900 biological_process IDA leukocyte migration
GO:0050901 biological_process IDA leukocyte tethering or rolling
GO:0051451 biological_process IEA myoblast migration
GO:0051451 biological_process ISS myoblast migration
GO:0051492 biological_process TAS regulation of stress fiber assem
GO:0051893 biological_process TAS regulation of focal adhesion ass
GO:0051894 biological_process IEA positive regulation of focal adh
GO:0051894 biological_process ISS positive regulation of focal adh
GO:0090002 biological_process IGI establishment of protein localiz
GO:0090002 biological_process IMP establishment of protein localiz
GO:1903140 biological_process IGI regulation of establishment of e
GO:1903140 biological_process IMP regulation of establishment of e
GO:1903347 biological_process IGI negative regulation of bicellula
GO:2000114 biological_process TAS regulation of establishment of c
GO:2000145 biological_process TAS regulation of cell motility

Homologs
Accession Description Species Homolog Type
UG_GRCm38WmN_uuJIeEEEJw08K0XS7A Rock1 10090 ortholog_one2one
UG_GRCz10oM_QRYYhWgjb0yYTNSi0AQ rock1 7955 ortholog_one2one

Loading