| Accession: |
UG_GRCh38-fOa_Vchq5c09R1cemh8FA
|
||
|---|---|---|---|
| Description: | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) [Source:HGNC Symbol;Acc:HGNC:11121] | ||
| Name(s) | SMPD2, ISC1, nSMase | ||
| Other IDs: | |||
| Tax ID | Position | Strand | Biotype(s) |
| 9606 |
6:109440763-109443919
|
+ | protein_coding |
Expressed in: Adipose, Adrenal, Bladder, Brain, Breast, Colon, Epithelial Cells, Heart, HEK-293 Cells, HEK-293F Cells, HEK-293T Cells, HK-2 Cells, Kidney, Kidney Cortex, Kidney Tubules, Liver, Lung, Muscle, Nephron Progenitor Cells, Nephrons, Ovary, Placenta, Proximal Tubule, Testis Enriched in: Epithelial Cells, HEK-293T Cells, HK-2 Cells, Kidney, Ovary, Testis Specific to: None |
| Parents | |||
|---|---|---|---|
| None |
| Children | ||||
|---|---|---|---|---|
| Accession | Name | Sequence Type | Position | Assembly |
| UT_GRCh38L8bgQaYQtv6Zfls6ILLb_g | SMPD2-003 | transcript | 6:109442571-109443556 (+) | GRCh38 |
| UT_GRCh38LGAbSUwM12vLlOSjv80-_w | SMPD2-001 | transcript | 6:109440763-109443919 (+) | GRCh38 |
| UT_GRCh38UQvmuqpVnLy1HdoqzNBJ3A | SMPD2-002 | transcript | 6:109441603-109442571 (+) | GRCh38 |
Expression Patterns
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Gene Ontology |
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|---|---|---|---|
| GO ID | Domain | Evidence Type | GO Description |
| GO:0004767 | molecular_function | IEA | sphingomyelin phosphodiesterase |
| GO:0005622 | cellular_component | IEA | intracellular |
| GO:0005886 | cellular_component | TAS | plasma membrane |
| GO:0005887 | cellular_component | TAS | integral component of plasma mem |
| GO:0005901 | cellular_component | IEA | caveola |
| GO:0006665 | biological_process | TAS | sphingolipid metabolic process |
| GO:0006684 | biological_process | TAS | sphingomyelin metabolic process |
| GO:0006687 | biological_process | TAS | glycosphingolipid metabolic proc |
| GO:0007166 | biological_process | TAS | cell surface receptor signaling |
| GO:0009612 | biological_process | IEA | response to mechanical stimulus |
| GO:0016020 | cellular_component | IEA | membrane |
| GO:0033209 | biological_process | TAS | tumor necrosis factor-mediated s |
| GO:0035556 | biological_process | IEA | intracellular signal transductio |
| GO:0044281 | biological_process | TAS | small molecule metabolic process |
| GO:0046513 | biological_process | IEA | ceramide biosynthetic process |
| GO:0046872 | molecular_function | IEA | metal ion binding |
| GO:0048011 | biological_process | TAS | neurotrophin TRK receptor signal |
| GO:0097190 | biological_process | TAS | apoptotic signaling pathway |
| GO:2000304 | biological_process | TAS | positive regulation of ceramide |
Homologs |
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| Accession | Description | Species | Homolog Type | ||
| UG_GRCm381SwfYGZKjixA822UF0z8Mg | Smpd2 | 10090 | ortholog_one2one | ||
| UG_GRCz10OCRfbxU57u-jqYOQZCwPZA | smpd2a | 7955 | ortholog_one2many | ||
| UG_GRCz10_-12cFJsKJw01ZnHDZGPrA | smpd2b | 7955 | ortholog_one2many | ||